It says Iranian intelligence agents have threatened to kidnap London staff and take them to Iran.
This is not the first time the BBC has taken the rare step of appealing to the UN for their safety.
Iran has previously denied the allegations, and accused BBC Persian of spreading false information to encourage its government’s overthrow.
The BBC’s legal representatives have urged the UN’s Human Rights Council (UNHCR) to take action on the issue.
An estimated 18 million Iranians – almost a quarter of Iran’s population – regularly use the BBC’s Persian service online, on radio or via satellite television.
But the Farsi language service is banned in Iran, and authorities there have previously detained people for alleged links to the BBC outlet.
In an internal survey of 102 BBC Persian staff, carried out in March 2020, 71 said they had experienced harassment. A third have also had one or both parents harassed or called in for questioning by Iranian authorities, and over half say they feel under pressure to leave their jobs.